Concepedia

Drug Toxicity Testing

Drug Toxicity Testing is a scientific methodology within preclinical drug development that employs in vitro models, particularly organ-on-chip systems, to assess the adverse effects of pharmaceutical compounds on human physiological functions, thereby differentiating it from efficacy-focused or in silico screening approaches.

752

Publications

41.7K

Citations

3.7K

Authors

1.2K

Institutions

Publications per year

2017–2026

149

Parents

Publications

752

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Dongeun Huh, Daniel C. Leslie, Benjamin D. Matthews et al. · Science Translational Medicine · 2012 · 988 citations · Full text

, , +17

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

, , +14

Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

Fred M. Gordin · Annals of Internal Medicine · 1984 · 708 citations

, , +10

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

Gail A. Van Norman · JACC Basic to Translational Science · 2019 · 663 citations · Full text

, , +15

Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury

Vishal S. Vaidya, Victoria Ramírez, Takaharu Ichimura et al. · American Journal of Physiology-Renal Physiology · 2005 · 652 citations

, , +15

1–5 of 752

Authors

3.7K

  1. BE
    Björn Ekwall

    Uppsala University, Sweden

    5 publications · 165 citations

    5

    h-index

  2. NG
    Nigel Greene

    Pfizer (United States), United States

    5 publications · 1.1K citations

    5

    h-index

  3. AP
    Albert P. Li

    In Vitro Admet Laboratories (United States), United States

    5 publications · 307 citations

    5

    h-index

  4. LK
    Laura K. Schnackenberg

    National Center for Toxicological Research, United States

    4 publications · 139 citations

    4

    h-index

  5. TH
    Thomas Härtung

    University of Konstanz, Germany

    4 publications · 151 citations

    4

    h-index

1–5 of 3.7K

Institutions

1.2K

  1. Pfizer (United States)

    New York, United States

    16 h-index

    68 publications

    17.2K citations

  2. National Institutes of Health

    Bethesda, United States

    14 h-index

    57 publications

    3.1K citations

  3. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    14 h-index

    39 publications

    3.6K citations

  4. Harvard University

    Cambridge, United States

    12 h-index

    41 publications

    11.3K citations

  5. Joint Research Centre

    Ispra, Italy

    10 h-index

    32 publications

    1.1K citations

  6. National Cancer Institute

    Bethesda, United States

    10 h-index

    34 publications

    1.9K citations

  7. United States Food and Drug Administration

    Silver Spring, United States

    10 h-index

    50 publications

    5.2K citations

  8. National Center for Toxicological Research

    Pine Bluff, United States

    10 h-index

    21 publications

    810 citations

1–8 of 1.2K

Venues

  1. PubMed

    Repository · 74 publications · 2.9K citations

    32

    h-index

  2. Toxicology in Vitro

    19 publications · 956 citations

    16

    h-index

  3. Regulatory Toxicology and Pharmacology

    RTP · 17 publications · 754 citations

    16

    h-index

  4. Scientific Reports

    12 publications · 1.1K citations

    12

    h-index

  5. Alternatives to Laboratory Animals

    11 publications · 432 citations

    11

    h-index

1–5