MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests

Inger Bondesson, Björn Ekwall, Sven Hellberg, +3

Cell Biology and Toxicology

AllergyMedicineHuman ToxicityToxicology TestingToxicology +5

Practical Aspects of the Validation of Toxicity Test Procedures

Michael Balls, Bas J. Blaauboer, Julia H. Fentem, +12

Alternatives to Laboratory Animals

Toxicity Test ProceduresMedicinePatient SafetyForensic ToxicologyToxicology Testing +5

Overview of the Final MEIC Results: II. The In Vitro--In Vivo Evaluation, Including the Selection of a Practical Battery of Cell Tests for Prediction of Acute Lethal Blood Concentrations in Humans

Björn Ekwall

Toxicology in Vitro

Practical BatteryLaboratory HematologyPreclinical Drug EvaluationMedicineCell Tests +9

MEIC Evaluation of Acute Systemic Toxicity: Part VI. The Prediction of Human Toxicity by Rodent LD50 Values and Results From 61 In Vitro Methods.

Björn Ekwall, Frank A. Barile, Argelia Castaño, +29

PubMed

ImmunologyToxicology TestingToxicological MechanismCytotoxicity AssaysBioanalysis +14

MEIC Evaluation of Acute Systemic Toxicity

Cecilia Clemedson, Elisabeth McFarlane-Abdulla, Marianne Andersson, +44

Alternatives to Laboratory Animals

Toxicology TestingDifferent Toxicity AssaysComparative ToxicologyEnvironmental ChemistryBioanalysis +19

Overview of the Final MEIC Results: I. The In Vitro--In Vitro Evaluation

Cecilia Clemedson, Björn Ekwall

Toxicology in Vitro

OocyteDevelopmental BiologyCell DivisionGenetic EngineeringIn Vitro Techniques +8

Cytotoxicity Evaluation of the First Ten MEIC Chemicals: Acute Lethal Toxicity in Man Predicted by Cytotoxicity in Five Cellular Assays and by Oral LD50 Tests in Rodents

Björn Ekwall, Inger Bondesson, José V. Castell, +8

Alternatives to Laboratory Animals

ImmunologyToxicology TestingCell ToxicologyCytotoxicity EvaluationPartial Least Squares +14

Comparison of in vivo acute lethal potency and in vitro cytotoxicity of 48 chemicals

R. Shrivastava, Claudine Deloménie, A. Chevalier, +4

Cell Biology and Toxicology

Preclinical Drug EvaluationPharmacologyPoisoningToxicologyExperimental Toxicology +4

MEIC Evaluation of Acute Systemic Toxicity

Björn Ekwall, Cecilia Clemedson, Balcarras Crafoord, +4

Alternatives to Laboratory Animals

Multicenter EvaluationToxicology TestingBioanalysisHematologySepsis +14

Correlation between cytotoxicity in vitro and LD₅₀‐values.

Björn Ekwall

Acta Pharmacologica et Toxicologica

Cell DeathComparative ToxicologyPharmacodynamic ModelingOxidative StressToxicological Mechanism +19