Concepedia

Long-term Potentiation

Long-Term Potentiation is a form of activity-dependent synaptic plasticity characterized by a persistent increase in synaptic efficacy at specific synapses following brief, high-frequency or coincident pre- and postsynaptic activation, and is widely regarded as a key cellular mechanism underlying learning and memory.

10.9K

Publications

1M

Citations

32.2K

Authors

4.1K

Institutions

Publications per year

2017–2026

1.9K

Variants

Ltp

Parents

Children

Publications

10.9K

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

T.V.P. Bliss, Terje Lømo · The Journal of Physiology · 1973 · 7.3K citations · Full text

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Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type

Guo‐Qiang Bi, Mu‐ming Poo · Journal of Neuroscience · 1998 · 4.8K citations · Full text

, , +17

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

, , +14

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Ganesh M. Shankar, Shaomin Li, Tapan Mehta et al. · Nature Medicine · 2008 · 3.7K citations · Full text

, , +14

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Richard Morris, Eric Anderson, Gary Lynch et al. · Nature · 1986 · 3.6K citations

, , +15

1–5 of 10.9K

Authors

32.2K

  1. ER
    Eric R. Kandel

    Columbia University, United States

    84 publications · 26.6K citations

    71

    h-index

  2. GL
    Gary Lynch

    University of California, Irvine, United States

    128 publications · 20K citations

    69

    h-index

  3. RA
    Roger A. Nicoll

    University of California, San Francisco, United States

    68 publications · 17K citations

    57

    h-index

  4. GL
    Graham L. Collingridge

    University of Bristol, United Kingdom

    76 publications · 12.4K citations

    51

    h-index

  5. RC
    Robert C. Malenka

    Stanford University, United States

    49 publications · 15.8K citations

    44

    h-index

1–5 of 32.2K

Institutions

4.1K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    156 h-index

    801 publications

    283.5K citations

  2. University of California, San Francisco

    San Francisco, United States

    101 h-index

    467 publications

    120.2K citations

  3. Columbia University

    New York, United States

    97 h-index

    617 publications

    159.7K citations

  4. University of California, Irvine

    Irvine, United States

    95 h-index

    862 publications

    112.3K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    80 h-index

    888 publications

    69.4K citations

  6. Johns Hopkins University

    Baltimore, United States

    79 h-index

    430 publications

    76.9K citations

  7. National Institutes of Health

    Bethesda, United States

    79 h-index

    441 publications

    72.9K citations

  8. Inserm

    Paris, France

    78 h-index

    810 publications

    70.2K citations

1–8 of 4.1K

Venues

  1. Journal of Neuroscience

    929 publications · 136K citations

    199

    h-index

  2. Neuron

    287 publications · 74K citations

    163

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 331 publications · 58.4K citations

    137

    h-index

  4. Nature

    149 publications · 83.1K citations

    124

    h-index

  5. Brain Research

    701 publications · 52.3K citations

    109

    h-index

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