Mark E. Fraley

A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability

Andrew G. Myers, Norma J. Tom, Mark E. Fraley et al. · Journal of the American Chemical Society · 1997 · 208 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox, Paul J. Coleman, Michael J. Breslin et al. · Journal of Medicinal Chemistry · 2008 · 156 citations · Full text

Medicine, Oncology, Pharmacology +13

Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors

Mark E. Fraley, William F. Hoffman, Robert S. Rubino et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 113 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Mark E. Fraley, Robert S. Rubino, William F. Hoffman et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacokinetics +16

Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the absolute configuration of natural dynemicin A

Andrew G. Myers, Mark E. Fraley, Norma J. Tom et al. · Chemistry & Biology · 1995 · 83 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13