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Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Medicinal ChemistryBiochemistryKdr Kinase InhibitorsCellular ActivityMedicineNatural SciencesRational Drug DesignPharmacotherapyAnti-cancer AgentDrug DevelopmentChemical BiologyPharmacologyDrug DiscoveryPhysical PropertiesDrug Resistance