Ruth Z. Rutledge

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

Edward B. Garon, Naiyer A. Rizvi, Rina Hui et al. · New England Journal of Medicine · 2015 · 6.2K citations · Full text

Medicine, Oncology, Pharmacology +17

Vascular Endothelial Growth Factor Receptor KDR Tyrosine Kinase Activity Is Increased by Autophosphorylation of Two Activation Loop Tyrosine Residues

Richard Kendall, Ruth Z. Rutledge, Xianzhi Mao et al. · Journal of Biological Chemistry · 1999 · 133 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells

Lars Edvinsson, Rikard Alm, Duncan Shaw et al. · European Journal of Pharmacology · 2002 · 116 citations

Medicine, Cardiology, Pharmacology +11

Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors

Mark E. Fraley, William F. Hoffman, Robert S. Rubino et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 113 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Mark E. Fraley, Robert S. Rubino, William F. Hoffman et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacokinetics +16