Kenneth L. Arrington

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Mark E. Fraley, Robert S. Rubino, William F. Hoffman et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacokinetics +16

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, R. M. Garbaccio, Kenneth L. Arrington et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 64 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis

Weikang Tao, Victoria J. South, Ronald E. Diehl et al. · Molecular and Cellular Biology · 2006 · 54 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors

Mark E. Fraley, Kenneth L. Arrington, Carolyn A. Buser et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

R. M. Garbaccio, Mark E. Fraley, Edward S. Tasber et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 47 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17