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Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Protein ChemistryMedicinal ChemistryPharmaceutical ScienceBiochemistryReduced Herg BindingNatural SciencesMedicinePhosphate Prodrug StrategyKinesin Spindle ProteinDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery