Concepedia

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

R. M. Garbaccio, Mark E. Fraley, Edward S. Tasber, Christy M. Olson, William F. Hoffman, Kenneth L. Arrington, Maricel Torrent, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton,

Bioorganic & Medicinal Chemistry Letters · 2006 · 47 citations · 5 references

DOIFull text

Open access

Concepts

References

5

Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Youwei Yan, Vinod Sardana, Bei Xu et al. · Journal of Molecular Biology · 2003 · 204 citations

, , +14

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP

Christopher D. Cox, Michael J. Breslin, Brenda J. Mariano et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 136 citations · Full text

, , +16

Prodrugs of anticancer agents

Achintya K. Sinhababu, Dhiren R. Thakker · Advanced Drug Delivery Reviews · 1996 · 105 citations

, , +12

A simple, rapid and efficient protocol for the selective phosphorylation of phenols with dibenzyl phosphite

Lee J. Silverberg, John L. Dillon, Purushotham Vemishetti · Tetrahedron Letters · 1996 · 76 citations

, , +4

An Improved Method for Lewis Acid Catalyzed Phosphoryl Transfer with Ti(<i>t</i>-BuO)<sub>4</sub>

Simon Jones, Dimitrios Selitsianos, Kate J. Thompson et al. · The Journal of Organic Chemistry · 2003 · 64 citations

, , +12