Dhiren R. Thakker

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Mildred K. Buening, Peter G. Wislocki, Wayne Levin et al. · Proceedings of the National Academy of Sciences · 1978 · 381 citations · Full text

Active Isomers, Optical Enantiomers, Pure Isomers +12

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

Dhiren R. Thakker, Haruhiko Yagi, H. Akagi et al. · Chemico-Biological Interactions · 1977 · 262 citations

Biochemistry, Medicine, Secondary Metabolite +6

Enhancing paracellular permeability by modulating epithelial tight junctions

Peter Ward, Tim K. Tippin, Dhiren R. Thakker · Pharmaceutical Science & Technology Today · 2000 · 220 citations

Cell Adhesion, Membrane Transport, Cell Trafficking +7

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

Dhiren R. Thakker, Haruhiko Yagi, Anthony Y.H. Lu et al. · Proceedings of the National Academy of Sciences · 1976 · 205 citations · Full text

Bioorganic Chemistry, Mutagenic 7,8-Diol-9,10-epoxides, Secondary Metabolite +16

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Liang-Shang Gan, Dhiren R. Thakker · Advanced Drug Delivery Reviews · 1997 · 171 citations

Pharmaceutical Science, Caco-2 Model, Biochemistry +7