Concepedia

Aqueous Solubility Optimization

Aqueous Solubility Optimization is a physicochemical property optimization method that specifically enhances the capacity of a compound to dissolve in water through systematic modification of molecular structure or formulation parameters.

328

Publications

15K

Citations

2.2K

Authors

542

Institutions

Publications per year

2017–2026

125

Parents

Publications

328

CyclodextrinsEnabling Excipients: Their Present and Future Use in Pharmaceuticals

Diane Oenning Thompson · Critical Reviews in Therapeutic Drug Carrier Systems · 1997 · 418 citations

, , +14

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

, , +16

Using Cocrystals To Systematically Modulate Aqueous Solubility and Melting Behavior of an Anticancer Drug

Christer B. Aakeröy, Safiyyah Forbes, J. Desper · Journal of the American Chemical Society · 2009 · 299 citations · Full text

, , +17

Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability

S. Manju, K. Sreenivasan · Journal of Colloid and Interface Science · 2011 · 293 citations

, , +14

Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure

Andrew G. Leach, Huw Jones, David A. Cosgrove et al. · Journal of Medicinal Chemistry · 2006 · 283 citations

, , +16

1–5 of 328

Authors

2.2K

  1. MI
    Minoru Ishikawa

    The University of Tokyo, Japan

    5 publications · 68 citations

    5

    h-index

  2. YH
    Yuichi Hashimoto

    The University of Tokyo, Japan

    5 publications · 68 citations

    5

    h-index

  3. JD
    José-Luis Díaz

    Almirall (Spain), Spain

    4 publications · 149 citations

    4

    h-index

  4. EL
    Emily Lin

    Neurocrine Biosciences (United States), United States

    4 publications · 149 citations

    4

    h-index

  5. SL
    Sandra Lechner

    Neurocrine Biosciences (United States), United States

    4 publications · 149 citations

    4

    h-index

1–5 of 2.2K

Institutions

542

  1. University of Auckland

    Auckland, New Zealand

    8 h-index

    42 publications

    1.7K citations

  2. China Pharmaceutical University

    Nanjing, China

    7 h-index

    57 publications

    2K citations

  3. Cancer Society of New Zealand

    Wellington, New Zealand

    6 h-index

    22 publications

    1.2K citations

  4. Bristol-Myers Squibb (United States)

    New York, United States

    6 h-index

    110 publications

    6K citations

  5. The University of Tokyo

    Tokyo, Japan

    6 h-index

    29 publications

    412 citations

  6. Hanyang University

    Seoul, South Korea

    5 h-index

    18 publications

    1.3K citations

  7. University of Copenhagen

    Copenhagen, Denmark

    5 h-index

    16 publications

    1.3K citations

  8. Pfizer (United States)

    New York, United States

    5 h-index

    60 publications

    4.3K citations

1–8 of 542

Venues

  1. Journal of Medicinal Chemistry

    52 publications · 3.3K citations

    32

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    16 publications · 443 citations

    13

    h-index

  3. ACS Medicinal Chemistry Letters

    14 publications · 428 citations

    13

    h-index

  4. Journal of Pharmaceutical Sciences

    8 publications · 495 citations

    8

    h-index

  5. European Journal of Pharmaceutical Sciences

    8 publications · 290 citations

    8

    h-index

1–5