Concepedia

Physicochemical Property Optimization

Physicochemical Property Optimization is a medicinal chemistry strategy that systematically modifies the molecular structure of a lead compound or prodrug to tune its intrinsic physical and chemical properties (e.g., lipophilicity, solubility, ionization, and stability) so as to achieve a target profile of absorption, distribution, metabolism, excretion, safety, and efficacy.

559

Publications

34.6K

Citations

2.5K

Authors

870

Institutions

Publications per year

2017–2026

260

Parents

Children

Publications

559

CHEM21 selection guide of classical- and less classical-solvents

Denis Prat, A.S. Wells, John Hayler et al. · Green Chemistry · 2015 · 2.1K citations · Full text

, , +10

Pharmaceutical Cocrystals and Their Physicochemical Properties

N. Schultheiss, Ann Newman · Crystal Growth & Design · 2009 · 1.5K citations · Full text

, , +17

admetSAR 2.0: web-service for prediction and optimization of chemical ADMET properties

Hongbin Yang, Chaofeng Lou, Lixia Sun et al. · Bioinformatics · 2018 · 1.4K citations

, , +16

Journal of Chemical and Pharmaceutical Research, 2015, 7(7):933-939

Ibeth Bolagay, Darwin Rueda Ortiz, Norman Soria Idrovo et al. · 2015 · 1.2K citations

, , +9

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

M. Paul Gleeson · Journal of Medicinal Chemistry · 2008 · 961 citations

, , +17

1–5 of 559

Authors

2.5K

  1. MJ
    Michael J. Waring

    University of Cambridge, United Kingdom

    4 publications · 1.3K citations

    4

    h-index

  2. RJ
    Robert J. Young

    GlaxoSmithKline (United Kingdom), United Kingdom

    3 publications · 221 citations

    3

    h-index

  3. BS
    Benjamín Sánchez-Lengeling

    University of Toronto, Canada

    3 publications · 453 citations

    3

    h-index

  4. CO
    Carlos Outeiral

    University of Oxford, United Kingdom

    3 publications · 453 citations

    3

    h-index

  5. BB
    Bernard Bataille

    Université de Montpellier, France

    3 publications · 70 citations

    3

    h-index

1–5 of 2.5K

Institutions

870

  1. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    11 h-index

    42 publications

    7.8K citations

  2. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    8 h-index

    35 publications

    4.5K citations

  3. King Saud University

    Riyadh, Saudi Arabia

    8 h-index

    10 publications

    254 citations

  4. Pfizer (United States)

    New York, United States

    6 h-index

    20 publications

    3.5K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    17 publications

    586 citations

  6. Tehran University of Medical Sciences

    Tehran, Iran

    5 h-index

    9 publications

    204 citations

  7. King Khalid University

    Abhā, Saudi Arabia

    5 h-index

    7 publications

    198 citations

  8. Eli Lilly (United States)

    Indianapolis, United States

    5 h-index

    17 publications

    575 citations

1–8 of 870

Venues

  1. Journal of Pharmaceutical Sciences

    16 publications · 1.3K citations

    14

    h-index

  2. Journal of Medicinal Chemistry

    16 publications · 3.3K citations

    14

    h-index

  3. International Journal of Pharmaceutics

    12 publications · 636 citations

    12

    h-index

  4. Journal of Chemical Information and Modeling

    JCIM · 9 publications · 336 citations

    9

    h-index

  5. Green Chemistry

    GC · 8 publications · 2.5K citations

    8

    h-index

1–5