Concepedia

Lipinski Rule Optimization

Lipinski Rule Optimization is a methodological framework in medicinal chemistry that systematically modifies molecular structures to ensure compliance with the Lipinski's Rule of Five, thereby enhancing their likelihood of favorable oral bioavailability while distinguishing itself from general physicochemical optimization techniques by specifically prioritizing adherence to these established criteria for drug-likeness.

48

Publications

1.5K

Citations

222

Authors

99

Institutions

Publications per year

2017–2026

33

Parents

Publications

48

Developing degraders: principles and perspectives on design and chemical space

Hannah J. Maple, Nat Clayden, Anne Baron et al. · MedChemComm · 2019 · 159 citations · Full text

, , +17

Virtual Screening in Lead Discovery: A Viewpoint

Tudor I. Oprea · Molecules · 2002 · 131 citations · Full text

, , +17

High throughput screening, docking, and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV

Anam Beg, Faez Iqbal Khan, Kevin A. Lobb et al. · Journal of Biomolecular Structure and Dynamics · 2018 · 73 citations

, , +17

Application of descriptors based on Lipinski’s rules in the QSPR study of aqueous solubilities

Pablo R. Duchowicz, Alan Talevi, Carolina L. Bellera et al. · Bioorganic & Medicinal Chemistry · 2007 · 56 citations

, , +15

Analysis of the Applicability and Use of Lipinski`s Rule for Central Nervous System Drugs

Thais Batista Fernandes, Mariana C. F. Segretti, Michelle Carneiro Polli et al. · Letters in Drug Design & Discovery · 2016 · 54 citations · Full text

, , +14

1–5 of 48

Authors

222

  1. GM
    Govind Mohan

    NIMS University, India

    2 publications · 43 citations

    2

    h-index

  2. FA
    Faizul Azam

    Qassim University, Saudi Arabia

    2 publications · 43 citations

    2

    h-index

  3. NT
    Neelaveni Thangavel

    Jazan University, Saudi Arabia

    2 publications · 43 citations

    2

    h-index

  4. MA
    Mohammad Amjad Kamal

    King Abdulaziz University, Saudi Arabia

    2 publications · 31 citations

    2

    h-index

  5. SS
    Syed Sayeed Ahmad

    Yeungnam University, South Korea

    2 publications · 31 citations

    2

    h-index

1–5 of 222

Institutions

99

  1. King Saud University

    Riyadh, Saudi Arabia

    4 h-index

    4 publications

    58 citations

  2. Integral University

    Lucknow, India

    2 h-index

    7 publications

    121 citations

  3. National Research Centre

    Giza, Egypt

    2 h-index

    2 publications

    28 citations

  4. King Abdulaziz University

    Jeddah, Saudi Arabia

    2 h-index

    2 publications

    31 citations

  5. Siksha O Anusandhan University

    Bhubaneswar, India

    1 h-index

    3 publications

    99 citations

  6. Minia University

    Minya, Egypt

    1 h-index

    5 publications

    55 citations

  7. Bharati Vidyapeeth Deemed University

    Pune, India

    1 h-index

    3 publications

    54 citations

  8. NIMS University

    Jaipur, India

    1 h-index

    1 publications

    29 citations

1–8 of 99

Venues

  1. Molecules

    3 publications · 164 citations

    3

    h-index

  2. Asian Journal of Pharmaceutical Research

    2 publications · 43 citations

    2

    h-index

  3. Biointerface Research in Applied Chemistry

    2 publications · 72 citations

    2

    h-index

  4. 2

    h-index

  5. Future Journal of Pharmaceutical Sciences

    2 publications · 97 citations

    2

    h-index

1–5