Passive Diffusion Optimization is a physicochemical property optimization strategy that specifically enhances the transcellular membrane permeability of drug-like molecules by modulating their molecular properties—such as lipophilicity, molecular weight, and hydrogen bonding capacity—to maximize passive diffusion while maintaining favorable pharmacokinetic and pharmacodynamic profiles.
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2017–2026
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Martin Oliver, Charlène Gadais, Júlia García‐Pindado et al. · RSC Advances · 2018 · 32 citations · Full text
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Barcelona Institute of Science and Technology
Barcelona, Spain
1 h-index
2 publications
64 citations
Charles River Laboratories (United Kingdom)
Tranent, United Kingdom
1 h-index
2 publications
24 citations
Joanneum Research
Graz, Austria
1 h-index
3 publications
36 citations
Institute for Research in Biomedicine
Bellinzona, Switzerland
1 h-index
2 publications
64 citations
FC Barcelona
Barcelona, Spain
1 h-index
2 publications
64 citations
CY Cergy Paris Université
Cergy-Pontoise, France
1 h-index
5 publications
160 citations
Institute for Research in Biomedicine
Barcelona, Spain
1 h-index
2 publications
64 citations
Laboratoire de Chimie Bactérienne
Marseille, France
1 h-index
5 publications
160 citations
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- International Journal of Pharmaceutics
1 publications · 12 citations
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- RSC Advances
1 publications · 32 citations
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