Concepedia

Caco-2 Permeability Optimization

Caco-2 Permeability Optimization is a physicochemical property optimization strategy that specifically enhances the predicted or experimental permeability of compounds across Caco-2 cell monolayers, a widely used in vitro model of human intestinal absorption, to improve oral bioavailability in drug development.

30

Publications

1.8K

Citations

266

Authors

68

Institutions

Publications per year

2017–2026

12

Parents

Publications

30

A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure

Arnaud Béduneau, Camille Tempesta, Stéphane Fimbel et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2014 · 206 citations

, , +10

The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved Permeability

Robert A. Conradi, Alien R. Hilgers, Norman F.H. Ho et al. · Pharmaceutical Research · 1992 · 204 citations

, , +16

Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

Liang‐Shang Gan, Dhiren R. Thakker · Advanced Drug Delivery Reviews · 1997 · 171 citations

, , +17

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Mikimasa Tanada, Minoru Tamiya, Atsushi Matsuo et al. · Journal of the American Chemical Society · 2023 · 148 citations

, , +17

Nanoemulsion based delivery system for improved bioaccessibility and Caco-2 cell monolayer permeability of green tea catechins

J. Anu Bhushani, P. Karthik, C. Anandharamakrishnan · Food Hydrocolloids · 2016 · 128 citations

, , +16

1–5 of 30

Authors

266

  1. YY
    Yuan Yao

    Purdue University West Lafayette, United States

    3 publications · 110 citations

    3

    h-index

  2. PM
    Pavel Martásek

    Charles University, Czechia

    2 publications · 53 citations

    2

    h-index

  3. KW
    Kim W. McIntyre

    Bristol-Myers Squibb (United States), United States

    2 publications · 76 citations

    2

    h-index

  4. KM
    Kathleen M. Gillooly

    Bristol-Myers Squibb (United States), United States

    2 publications · 76 citations

    2

    h-index

  5. LS
    Luisa Salter–Cid

    Bristol-Myers Squibb (United States), United States

    2 publications · 76 citations

    2

    h-index

1–5 of 266

Institutions

68

  1. Purdue University West Lafayette

    West Lafayette, United States

    3 h-index

    5 publications

    192 citations

  2. Bristol-Myers Squibb (United States)

    New York, United States

    2 h-index

    81 publications

    2.7K citations

  3. University of California, Irvine

    Irvine, United States

    2 h-index

    5 publications

    131 citations

  4. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    2 h-index

    4 publications

    106 citations

  5. Northwestern University

    Evanston, United States

    2 h-index

    7 publications

    184 citations

  6. Charles University

    Prague, Czechia

    2 h-index

    2 publications

    53 citations

  7. Biocon (India)

    Bengaluru, India

    1 h-index

    8 publications

    184 citations

  8. Sanofi (Germany)

    Frankfurt am Main, Germany

    1 h-index

    11 publications

    132 citations

1–8 of 68

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 179 citations

    5

    h-index

  2. Pharmaceutical Research

    4 publications · 385 citations

    4

    h-index

  3. Journal of Pharmaceutical Sciences

    2 publications · 35 citations

    2

    h-index

  4. European Journal of Pharmaceutics and Biopharmaceutics

    EJPB · 2 publications · 219 citations

    2

    h-index

  5. Food Hydrocolloids

    2 publications · 158 citations

    2

    h-index

1–5