Jeffrey Roppe

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

Receptor Antagonist, Psychopharmacology, Pharmacotherapy +17

Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

Terence G. Hamill, Stephen M. Krause, Christine Ryan et al. · Synapse · 2005 · 152 citations

[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

Nicholas D. P. Cosford, Jeffrey Roppe, Lida Tehrani et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 146 citations · Full text

Biochemistry, G Protein-coupled Receptor, Medicine +9

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine)

Jeffery J. Anderson, Margaret Bradbury, Darlene R. Giracello et al. · European Journal of Pharmacology · 2003 · 136 citations

Biochemistry, Functional Selectivity, Medicine +11

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist

J. S. Swaney, Charles W. Chapman, Lucia Correa et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 126 citations