Concepedia

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, R. M. Garbaccio, Kenneth L. Arrington, William F. Hoffman, Edward S. Tasber, Paul J. Coleman, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Christine Fernandes,

Bioorganic & Medicinal Chemistry Letters · 2006 · 64 citations · 10 references

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10

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty et al. · Science · 1999 · 1.7K citations

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Anne Blangy, Heidi A. Lane, Pierre d'Hérin et al. · Cell · 1995 · 963 citations · Full text

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Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

Weikang Tao, Victoria J. South, Yun Zhang et al. · Cancer Cell · 2005 · 271 citations · Full text

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A Robotics-Based Automated Assay for Inorganic and Organic Phosphates

Elizabeth B. Cogan, G. Bruce Birrell, O. Hayes Griffith · Analytical Biochemistry · 1999 · 175 citations

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Mitotic Kinesin Inhibitors Induce Mitotic Arrest and Cell Death in Taxol-resistant and -sensitive Cancer Cells

Adam I. Marcus, Ulf Peters, Shala L. Thomas et al. · Journal of Biological Chemistry · 2005 · 170 citations · Full text

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