Christine Fernandes

RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Michael Carleton, Mao Mao, Matthew C. Biery et al. · Molecular and Cellular Biology · 2006 · 123 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

Lata T. Gooljarsingh, Christine Fernandes, Kang Yan et al. · Proceedings of the National Academy of Sciences · 2006 · 119 citations

Medicine, Medicinal Chemistry, Pharmacology +13

3-Aminopyrrolidinone Farnesyltransferase Inhibitors:  Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

Ian M. Bell, Steven N. Gallicchio, Marc Abrams et al. · Journal of Medicinal Chemistry · 2002 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, R. M. Garbaccio, Kenneth L. Arrington et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 64 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Potent <i>N</i>-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Mark T. Bilodeau, Adrienne E. Balitza, Timothy J. Koester et al. · Journal of Medicinal Chemistry · 2004 · 60 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17