Christine Fernandes

RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Michael Carleton, Mao Mao, Matthew C. Biery et al. · Molecular and Cellular Biology · 2006 · 122 citations · Full text

Cell Death, Cytoskeleton, Cell Cycle +16

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

Lata T. Gooljarsingh, Christine Fernandes, Kang Yan et al. · Proceedings of the National Academy of Sciences · 2006 · 118 citations · Full text

Biochemical Rationale, Drug Target, Drug Resistance +19

3-Aminopyrrolidinone Farnesyltransferase Inhibitors:  Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

Ian M. Bell, Steven N. Gallicchio, Marc Abrams et al. · Journal of Medicinal Chemistry · 2002 · 84 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Pharmacotherapy +16

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, R. M. Garbaccio, Kenneth L. Arrington et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 63 citations · Full text

Protein Function, Biochemistry, Natural Sciences +6

Potent <i>N</i>-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Mark T. Bilodeau, Adrienne E. Balitza, Timothy J. Koester et al. · Journal of Medicinal Chemistry · 2004 · 60 citations · Full text

Drug Target, Pharmacotherapy, Molecular Pharmacology +20