RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

Michael Carleton, Mao Mao, Matthew C. Biery, +7

Molecular and Cellular Biology

Cell DeathCytoskeletonCell CycleCancer BiologyTumor Biology +14

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

Lata T. Gooljarsingh, Christine Fernandes, Kang Yan, +12

Proceedings of the National Academy of Sciences

Biochemical RationaleDrug TargetDrug ResistanceMedicinal ChemistryHsp90 Inhibitor Geldanamycin +17

3-Aminopyrrolidinone Farnesyltransferase Inhibitors:  Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

Ian M. Bell, Steven N. Gallicchio, Marc Abrams, +27

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical Chemistry +14

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, R. M. Garbaccio, Kenneth L. Arrington, +20

Bioorganic & Medicinal Chemistry Letters

Protein FunctionBiochemistryNatural SciencesMolecular BiologyKinesin Spindle Protein +4

Potent <i>N</i>-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Mark T. Bilodeau, Adrienne E. Balitza, Timothy J. Koester, +21

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyMolecular PharmacologyMedicinal ChemistryVivo Potency +18

Dual Protein Farnesyltransferase−Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents

S. J. DESOLMS, Terrence M. Ciccarone, Suzanne C. MacTough, +14

Journal of Medicinal Chemistry

Potent Dual InhibitorsMedicinal ChemistryBioorganic ChemistryBiochemistryProtein Farnesyltransferase +12

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors

Mark E. Fraley, Kenneth L. Arrington, Carolyn A. Buser, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceIndolyl Quinolinone ClassBiochemistryMedicine +10

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

R. M. Garbaccio, Mark E. Fraley, Edward S. Tasber, +21

Bioorganic & Medicinal Chemistry Letters

Protein ChemistryMedicinal ChemistryPharmaceutical ScienceBiochemistryReduced Herg Binding +9

Design and Biological Activity of (<i>S</i>)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Ian M. Bell, Steven N. Gallicchio, Marc Abrams, +21

Journal of Medicinal Chemistry

3-Aminopyrrolidinone Farnesyltransferase InhibitorPharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +16

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase

John T. Sisko, Thomas J. Tucker, Mark T. Bilodeau, +16

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicinePharmacotherapyAnti-cancer Agent +3