Concepedia

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone

Pei‐Pei Kung, Lee Funk, Jerry Meng, Michael Collins, Joe Z. Zhou, M. Catherine Johnson, Anne Ekker, Jeff Wang, Pramod P. Mehta, Min-Jean Yin,

Bioorganic & Medicinal Chemistry Letters · 2008 · 53 citations · 15 references

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15

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

Andrea Basso, David B. Solit, Gabriela Chiosis et al. · Journal of Biological Chemistry · 2002 · 626 citations · Full text

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

James P. Grenert, W. Patrick Sullivan, Patrick Fadden et al. · Journal of Biological Chemistry · 1997 · 570 citations · Full text

, , +16

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

Udai Banerji, Anne O’Donnell, Michelle Scurr et al. · Journal of Clinical Oncology · 2005 · 491 citations · Full text

, , +17

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

Paul A. Brough, Wynne Aherne, Xavier Barril et al. · Journal of Medicinal Chemistry · 2007 · 445 citations · Full text

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Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer

Matthew P. Goetz, David O. Toft, Joel M. Reid et al. · Journal of Clinical Oncology · 2005 · 334 citations · Full text

, , +17