Pei‐Pei Kung

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

J. Jean Cui, Michelle Tran‐Dubé, Hong Shen et al. · Journal of Medicinal Chemistry · 2011 · 905 citations · Full text

Drug Target, Lead Series, Chemical Biology +20

Structure−Activity Relationships of Novel 2-Substituted Quinazoline Antibacterial Agents

Pei‐Pei Kung, Martin D. Casper, Kimberley L. Cook et al. · Journal of Medicinal Chemistry · 1999 · 225 citations

Antibacterial Agents, Antimicrobial Drug Discovery, Compound 22 +14

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Alexei Brooun, K.S. Gajiwala, Ya‐Li Deng et al. · Nature Communications · 2016 · 158 citations · Full text

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (<i>R</i>)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (PF-06821497)

Pei‐Pei Kung, Patrick Bingham, Alexei Brooun et al. · Journal of Medicinal Chemistry · 2017 · 125 citations · Full text

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

Pei‐Pei Kung, Buwen Huang, Gang Zhang et al. · Journal of Medicinal Chemistry · 2009 · 73 citations · Full text

Pharmaceutical Science, Chemical Biology, Pharmaceutical Chemistry +16