Michelle Tran‐Dubé

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

J. Jean Cui, Michelle Tran‐Dubé, Hong Shen et al. · Journal of Medicinal Chemistry · 2011 · 905 citations · Full text

Drug Target, Lead Series, Chemical Biology +20

A peptide-catalyzed asymmetric Stetter reaction

Steven M. Mennen, Jarred T. Blank, Michelle Tran‐Dubé et al. · Chemical Communications · 2004 · 134 citations

Intramolecular Stetter Reaction, Test Substrate, Novel Organocatalysts +13

Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 <i>H</i> -[1,2,3]triazolo[4,5- <i>b</i> ]pyrazin-6-yl)-1 <i>H</i> -pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

J. Jean Cui, Michele McTigue, Mitchell D. Nambu et al. · Journal of Medicinal Chemistry · 2012 · 103 citations · Full text

Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation

Hui‐Qi Ni, Ilia Kevlishvili, Pranali G. Bedekar et al. · Nature Communications · 2020 · 61 citations · Full text

Lessons from (<i>S</i>)-6-(1-(6-(1-Methyl-1<i>H</i>-pyrazol-4-yl)-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an Inhibitor of Receptor Tyrosine Kinase c-Met with High Protein Kinase Selectivity but Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats

J. Jean Cui, Hong Shen, Michelle Tran‐Dubé et al. · Journal of Medicinal Chemistry · 2013 · 39 citations · Full text

Compound 8, Chemoprevention Strategy, Cardiovascular Pharmacology +22