Alexei Brooun

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

Beili Wu, Ellen Y. T. Chien, Clifford D. Mol et al. · Science · 2010 · 1.7K citations

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey et al. · Journal of Medicinal Chemistry · 2014 · 571 citations · Full text

Resensitization to Crizotinib by the Lorlatinib<i>ALK</i>Resistance Mutation L1198F

Alice T. Shaw, Luc Friboulet, Ignaty Leshchiner et al. · New England Journal of Medicine · 2015 · 479 citations · Full text

Oncogenic Agent, Medicine, Genetics +15

A Dose-Response Study of Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> Biofilms

Alexei Brooun, Songhua Liu, Kim Lewis · Antimicrobial Agents and Chemotherapy · 2000 · 471 citations · Full text

Antimicrobial Resistance Gene, Antimicrobial Susceptibility, Health Sciences +11

Acquired Resistance to Crizotinib from a Mutation in <i>CD74</i>–<i>ROS1</i>

Mark M. Awad, Ryohei Katayama, Michele McTigue et al. · New England Journal of Medicine · 2013 · 408 citations · Full text

Genome Instability, Same Resistance Mutation, Oncogenic Agent +14