Pazopanib, a Multikinase Angiogenesis Inhibitor, in Patients With Relapsed or Refractory Advanced Soft Tissue Sarcoma: A Phase II Study From the European Organisation for Research and Treatment of Cancer–Soft Tissue and Bone Sarcoma Group (EORTC Study 62043)

Stefan Sleijfer, Isabelle Ray‐Coquard, Zsuzsa Pápai, +10

Journal of Clinical Oncology

OncologyAngiogenesisBone Sarcoma GroupSoft Tissue SarcomaPharmacology +12

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies

Udai Banerji, Anne O’Donnell, Michelle Scurr, +12

Journal of Clinical Oncology

Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group

Maria Dêbiec‐Rychter, Herlinde Dumez, Ian Judson, +11

European Journal of Cancer

Surgical OncologyBone Sarcoma GroupGastrointestinal OncologyMedicinePathology +6

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

David Olmos, Sophie Postel‐Vinay, L Rhoda Molife, +12

The Lancet Oncology

Anti-igf-1r Antibody FigitumumabMedicineImmunologyPathologyPreliminary Activity +5

Imatinib pharmacokinetics in patients with gastrointestinal stromal tumour: a retrospective population pharmacokinetic study over time. EORTC Soft Tissue and Bone Sarcoma Group

Ian Judson, Peiming Ma, Bin Peng, +8

Cancer Chemotherapy and Pharmacology

Imatinib PharmacokineticsOncologyBone Sarcoma GroupGastrointestinal OncologyMedicine +6

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells

Santhosh V. Kumar, Pei Xuan Er, Kynan T. Lawlor, +8

Development

Pegylated liposomal doxorubicin, an effective, well-tolerated treatment for refractory aggressive fibromatosis

Anastasia Constantinidou, Robin L. Jones, Michelle Scurr, +2

European Journal of Cancer

FibrosisWell-tolerated TreatmentPathologyRefractory Aggressive FibromatosisLiposomal Doxorubicin +3

Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome

Susan Lapthorne, Prue M. Pereira-Fantini, Fiona Fouhy, +10

Gut Microbes

Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease

Prue M. Pereira-Fantini, Susan Lapthorne, Susan A. Joyce, +11

Journal of Hepatology

InflammationHepatologyBiliary TractLiver PhysiologyImmunology +9

Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

Jessica M. Vanslambrouck, Sean B. Wilson, Ker Sin Tan, +9

Nature Communications