Andrea Basso

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas et al. · Nature · 2005 · 1.3K citations · Full text

Signal Transduction, Braf Mutation, Genetic Disorder +6

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

Andrea Basso, David B. Solit, Gabriela Chiosis et al. · Journal of Biological Chemistry · 2002 · 620 citations · Full text

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.

Mark M. Moasser, Andrea Basso, Steven D. Averbuch et al. · PubMed · 2001 · 508 citations

Breast Oncology, Her2-driven Signaling, Tumor Biology +20

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

Roberto Bianco, Incheol Shin, Christoph A. Ritter et al. · Oncogene · 2003 · 452 citations

Medicine, Receptor Tyrosine Kinase, Pharmacology +5

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

Olivera M. Grbovic, Andrea Basso, Ayana Sawai et al. · Proceedings of the National Academy of Sciences · 2005 · 306 citations · Full text