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Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer

DOIFull Paper Access

334

Citations

58

References

2005

Year

Matthew P. Goetz, David O. Toft, Joel M. Reid, Matthew M. Ames, Bridget Stensgard, Stephanie L. Safgren, Araba A. Adjei, Jeff A. Sloan, Pamela J. Atherton, Vlad C. Vasile,
Journal of Clinical Oncology

Abstract

The MTD of weekly 17-AAG is 308 mg/m(2). 17-AAG induced Hsp70 in PBMCs, indicating that Hsp90 has been affected. Further evaluation of 17-AAG is ongoing using a twice-weekly regimen, and this schedule of 17-AAG is being tested in combination with chemotherapy.

References

YearCitations

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