Concepedia

Chaperone-mediated Folding

Chaperone-Mediated Folding is a protein folding mechanism in which molecular chaperones selectively bind to nascent or misfolded polypeptides to prevent aggregation and facilitate proper folding through transient, non-covalent interactions, distinguishing it from spontaneous or co-translational folding pathways.

4.9K

Publications

394.3K

Citations

16.7K

Authors

2.8K

Institutions

Publications per year

2017–2026

809

Variants

Chaperone-assisted Protein Folding

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Publications

4.9K

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Martin Schröder, Randal J. Kaufman · Annual Review of Biochemistry · 2005 · 3K citations · Full text

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

Ann–Hwee Lee, Neal N. Iwakoshi, Laurie H. Glimcher · Molecular and Cellular Biology · 2003 · 2.1K citations · Full text

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Alpha-crystallin can function as a molecular chaperone.

Joseph Horwitz · Proceedings of the National Academy of Sciences · 1992 · 1.8K citations · Full text

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Small heat shock proteins are molecular chaperones.

Ursula Jakob, Matthias Gaestel, Katrin Engel et al. · Journal of Biological Chemistry · 1993 · 1.4K citations · Full text

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Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

, , +17

1–5 of 4.9K

Authors

16.7K

  1. JB
    Johannes Büchner

    Technical University of Munich, Germany

    94 publications · 14.6K citations

    62

    h-index

  2. FU
    F. Ulrich Hartl

    Max Planck Institute of Biochemistry, Germany

    84 publications · 18.3K citations

    60

    h-index

  3. BB
    Bernd Bukau

    Heidelberg University, Germany

    75 publications · 13.4K citations

    59

    h-index

  4. JF
    Judith Frydman

    Stanford University, United States

    58 publications · 8.2K citations

    42

    h-index

  5. MP
    Matthias P. Mayer

    Heidelberg University, Germany

    41 publications · 5.9K citations

    35

    h-index

1–5 of 16.7K

Institutions

2.8K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    97 h-index

    455 publications

    107.1K citations

  2. University of Michigan

    Ann Arbor, United States

    64 h-index

    413 publications

    46.9K citations

  3. Heidelberg University

    Heidelberg, Germany

    62 h-index

    376 publications

    51.3K citations

  4. Max Planck Institute of Biochemistry

    Martinsried, Germany

    60 h-index

    357 publications

    54K citations

  5. National Institutes of Health

    Bethesda, United States

    58 h-index

    355 publications

    36.3K citations

  6. Stanford University

    Stanford, United States

    56 h-index

    314 publications

    34.7K citations

  7. Technical University of Munich

    Munich, Germany

    52 h-index

    398 publications

    38.8K citations

  8. Yale University

    New Haven, United States

    52 h-index

    208 publications

    43.4K citations

1–8 of 2.8K

Venues

  1. Journal of Biological Chemistry

    JBC · 712 publications · 58.1K citations

    122

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 246 publications · 28.7K citations

    100

    h-index

  3. The EMBO Journal

    123 publications · 23.3K citations

    93

    h-index

  4. Cell

    76 publications · 22.4K citations

    72

    h-index

  5. Nature

    75 publications · 27.9K citations

    71

    h-index

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