Concepedia

Aggregation Suppression

Aggregation Suppression is a biochemical mechanism that specifically inhibits the aberrant association of misfolded or unfolding-prone proteins into insoluble aggregates during chaperone-mediated folding, protein refolding, or proteostatic stress, thereby preserving proteome integrity and functional protein conformation.

178

Publications

14K

Citations

794

Authors

286

Institutions

Publications per year

2017–2026

56

Parents

Publications

178

<i>Escherichia coli</i> maltose‐binding protein is uncommonly effective at promoting the solubility of polypeptides to which it is fused

Rachel B. Kapust, David S. Waugh · Protein Science · 1999 · 964 citations · Full text

, , +16

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

Christopher J. Cummings, Michael A. Mancini, Barbara Antalffy et al. · Nature Genetics · 1998 · 743 citations

, , +14

Polyfluorenes with Polyphenylene Dendron Side Chains:  Toward Non-Aggregating, Light-Emitting Polymers

Sepas Setayesh, Andrew C. Grimsdale, Tanja Weil et al. · Journal of the American Chemical Society · 2001 · 627 citations

, , +17

Supercharging Proteins Can Impart Unusual Resilience

Michael S. Lawrence, Kevin J. Phillips, David R. Liu · Journal of the American Chemical Society · 2007 · 547 citations · Full text

, , +17

The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation

Tsutomu Arakawa, Kouhei Tsumoto · Biochemical and Biophysical Research Communications · 2003 · 359 citations

, , +14

1–5 of 178

Authors

794

  1. BI
    Boris I. Kurganov

    A N Bach Institute of Biochemistry, Russia

    4 publications · 123 citations

    4

    h-index

  2. HE
    Heath Ecroyd

    University of Wollongong, Australia

    4 publications · 228 citations

    4

    h-index

  3. BL
    Bernhardt L. Trout

    Massachusetts Institute of Technology, United States

    4 publications · 572 citations

    4

    h-index

  4. HH
    Harm H. Kampinga

    University of Groningen, Netherlands

    4 publications · 368 citations

    4

    h-index

  5. RJ
    Ralf J. Sommer

    Max Planck Institute for Developmental Biology, Germany

    2 publications · 78 citations

    3

    h-index

1–5 of 794

Institutions

286

  1. University of Cambridge

    Cambridge, United Kingdom

    7 h-index

    32 publications

    2.9K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    7 h-index

    17 publications

    2.1K citations

  3. University of Toronto

    Toronto, Canada

    5 h-index

    13 publications

    1.4K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    10 publications

    3K citations

  5. Tohoku University

    Sendai, Japan

    4 h-index

    22 publications

    1.1K citations

  6. Harvard University

    Cambridge, United States

    4 h-index

    13 publications

    2.2K citations

  7. German Center for Neurodegenerative Diseases

    Bonn, Germany

    4 h-index

    15 publications

    697 citations

  8. University of Wollongong

    Wollongong, Australia

    4 h-index

    12 publications

    936 citations

1–8 of 286

Venues

  1. Journal of Biological Chemistry

    JBC · 15 publications · 1.1K citations

    15

    h-index

  2. Biochemistry

    8 publications · 912 citations

    8

    h-index

  3. Protein Science

    PS · 6 publications · 1.4K citations

    6

    h-index

  4. 5

    h-index

  5. RSC Advances

    4 publications · 114 citations

    4

    h-index

1–5