Christopher J. Cummings

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

Christopher J. Cummings, Michael A. Mancini, Barbara Antalffy et al. · Nature Genetics · 1998 · 742 citations

Protein Function, Protein Assembly, Protein Folding +9

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

Pamela J. Skinner, Beena T. Koshy, Christopher J. Cummings et al. · Nature · 1997 · 527 citations

Protein Function, Signal Transduction, Natural Sciences +6

Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice

Christopher J. Cummings, Eyal Reinstein, Yaling Sun et al. · Neuron · 1999 · 504 citations · Full text

Chromatin, Genome Instability, Cell Regulation +5

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

Christopher J. Cummings · Human Molecular Genetics · 2001 · 486 citations

Polyglutamine-Expanded Androgen Receptors Form Aggregates That Sequester Heat Shock Proteins, Proteasome Components and SRC-1, and Are Suppressed by the HDJ-2 Chaperone

David L. Stenoien, Christopher J. Cummings, Henry P. Adams et al. · Human Molecular Genetics · 1999 · 447 citations · Full text

Androgen Receptor, Molecular Biology, Cellular Physiology +21