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The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Jane L. Wang, David C. Limburg, Matthew J. Graneto, John R. Springer, Joseph Rogier Bruce Hamper, Subo Liao, Jennifer L. Pawlitz, Ravi G. Kurumbail, Timothy J. Maziasz, John J. Talley,

Bioorganic & Medicinal Chemistry Letters · 2010 · 335 citations · 5 references

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References

5

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

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The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

Daniel Picot, Patrick J. Loll, R. Michael Garavito · Nature · 1994 · 1.3K citations

, , +11

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

Joseph P. Portanova, Y Zhang, Graham Anderson et al. · The Journal of Experimental Medicine · 1996 · 420 citations · Full text

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Inhibition of Cyclooxygenase-2 Rapidly Reverses Inflammatory Hyperalgesia and Prostaglandin E2 Production

Yan Zhang, Alex Shaffer, Joseph P. Portanova et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 231 citations

, , +15

Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors

James K. Gierse, Maureen A. Nickols, K. Leahy et al. · European Journal of Pharmacology · 2008 · 34 citations

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