Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse, +9

Nature

InflammationMedicinal ChemistryAnti-inflammatoryBiochemistryMedicine +8

Structural insights into the stereochemistry of the cyclooxygenase reaction

James R. Kiefer, Jennifer L. Pawlitz, Kirby T. Moreland, +9

Nature

Aldehyde DehydrogenaseBiochemistryNatural SciencesStereoselective SynthesisChemical Biology +1

Three-dimensional structure of human cytomegalovirus protease

Huey‐Sheng Shieh, Ravi G. Kurumbail, Anna M. Stevens, +8

Nature

Virus StructureViral ReplicationProtein FoldingThree-dimensional StructureMolecular Biology +4

Ophthalmic Manifestations of Infections with Cryptococcus neoformans in Patients with the Acquired Immunodeficiency Syndrome

Philippe Kestelyn, H Taelman, Jos Bogaerts, +5

American Journal of Ophthalmology

Primary ImmunodeficiencyOphthalmic ManifestationsOphthalmologyMedicineCryptococcus Neoformans +3

Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor

Yiqing Feng, John J. Likos, Leiming Zhu, +9

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Protein ChemistryCatalytic DomainHydroxamic Acid InhibitorBackbone DynamicsBiochemistry +7

Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex

John J. Parlow, Brenda L. Case, Thomas A. Dice, +14

Journal of Medicinal Chemistry

Combinatorial ChemistryCrystal StructurePharmacotherapyParallel SynthesisChemical Biology +14

Design, Synthesis, and Crystal Structure of Selective 2-Pyridone Tissue Factor VIIa Inhibitors

John J. Parlow, Ravi G. Kurumbail, Roderick A. Stegeman, +3

Journal of Medicinal Chemistry

Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial

Anna M. Stevens, Philippe Kestelyn, Dirk De Bacquer, +1

Acta Ophthalmologica

4-Fluorinated<scp>l</scp>-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain

E. Ann Hallinan, Steven W. Kramer, Stephen C. Houdek, +7

Organic & Biomolecular Chemistry

Molecular PharmacologyMedicinal ChemistryInos ProgramBioorganic ChemistryBiochemistry +13

Synthesis and Crystal Structures of Substituted Benzenes and Benzoquinones as Tissue Factor VIIa Inhibitors

John J. Parlow, Anna M. Stevens, Roderick A. Stegeman, +3

Journal of Medicinal Chemistry