James K. Gierse

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

James K. Gierse, Scott D. Hauser, David Creely et al. · Biochemical Journal · 1995 · 417 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

James K. Gierse, Joseph J. McDonald, Scott D. Hauser et al. · Journal of Biological Chemistry · 1996 · 411 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli

Steven P. Allen, Joseph O. Polazzi, James K. Gierse et al. · Journal of Bacteriology · 1992 · 299 citations · Full text

Life Sciences, Microbiology, Molecular Biology +15

Kinetic basis for selective inhibition of cyclo-oxygenases

James K. Gierse, Carol M. Koboldt, Mark C. Walker et al. · Biochemical Journal · 1999 · 279 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13