Joseph J. McDonald

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

Inflammation, Medicinal Chemistry, Anti-inflammatory +10

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

James K. Gierse, Joseph J. McDonald, Scott D. Hauser et al. · Journal of Biological Chemistry · 1996 · 410 citations · Full text

Assessment of Docking Poses:  Interactions-Based Accuracy Classification (IBAC) versus Crystal Structure Deviations

Romano T. Kroemer, Anna Vulpetti, Joseph J. McDonald et al. · Journal of Chemical Information and Computer Sciences · 2004 · 125 citations

Crystal Structure, Drug Target, Engineering +20

Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor

Yiqing Feng, John J. Likos, Leiming Zhu et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2002 · 100 citations

Protein Chemistry, Catalytic Domain, Hydroxamic Acid Inhibitor +9

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell et al. · Journal of Medicinal Chemistry · 2010 · 97 citations · Full text

Spare Mmp-1, Pharmacotherapy, Pharmaceutical Chemistry +17