James R. Kiefer

Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

James R. Kiefer, Mao Chen, Jeffrey C. Braman et al. · Nature · 1998 · 520 citations

Natural Sciences, Protein X-ray Crystallography, Dna Replication +5

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Maia Vinogradova, Victor Gehling, Amy Gustafson et al. · Nature Chemical Biology · 2016 · 343 citations · Full text

Drug-tolerant Cancer Cells, Medicine, Anti-cancer Agent +7

A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385

Scott W. Rowlinson, James R. Kiefer, Jeffery J. Prusakiewicz et al. · Journal of Biological Chemistry · 2003 · 338 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +16

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Jane L. Wang, David C. Limburg, Matthew J. Graneto et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 324 citations · Full text

Medicinal Chemistry, Novel Benzopyran Class, Favorable Human Half-life +11

Structural insights into the stereochemistry of the cyclooxygenase reaction

James R. Kiefer, Jennifer L. Pawlitz, Kirby T. Moreland et al. · Nature · 2000 · 271 citations

Aldehyde Dehydrogenase, Biochemistry, Natural Sciences +3