‘In silico’ simulations to assess the ‘in vivo’ consequences of ‘in vitro’ metabolic drug–drug interactions

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 791 citations

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

H.K. Crewe, MS Lennard, GT Tucker et al. · British Journal of Clinical Pharmacology · 1992 · 468 citations · Full text

Cytochrome P4502d6, Pharmacotherapy, Cyp2d6 Activity +22

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 399 citations

ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION

Nina Isoherranen, Kent L. Kunze, Kyle E. Allen et al. · Drug Metabolism and Disposition · 2004 · 272 citations

Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

H.K. Crewe, S. W. Ellis, M. S. Lennard et al. · Biochemical Pharmacology · 1997 · 223 citations

Molecular Pharmacology, Biochemistry, Medicine +11