Concepedia

Metabolism Interactions

Metabolism Interaction is a type of drug interaction that occurs when one drug alters the metabolic pathway of another drug, primarily through enzyme induction or inhibition in the liver or other tissues, thereby affecting its rate of biotransformation and subsequent pharmacological activity.

207

Publications

10.8K

Citations

850

Authors

275

Institutions

Publications per year

2017–2026

17

Variants

Metabolic Drug-drug Interactions

Parents

Publications

207

Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

Rajinder Bhardwaj, Hartmut Glaeser, Laurent Becquemont et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 533 citations · Full text

, , +17

Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.

C.K. Atal, Raghvendra K. Dubey, Jatinder Singh · Journal of Pharmacology and Experimental Therapeutics · 1985 · 353 citations

, , +17

Metabolic Interactions of Alcohol and Folate

Charles H. Halsted, Jesus A. Villanueva, Angela M. Devlin et al. · Journal of Nutrition · 2002 · 326 citations · Full text

, , +12

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

Richard J. Lewis, William Trager, Kenneth K. Chan et al. · Journal of Clinical Investigation · 1974 · 284 citations · Full text

, , +12

St John's Wort increases expression of P‐glycoprotein: Implications for drug interactions

Martina Hennessy, Dermot Kelleher, Paul Spiers et al. · British Journal of Clinical Pharmacology · 2002 · 278 citations · Full text

, , +17

1–5 of 207

Authors

850

  1. WT
    William Trager

    University of Washington, United States

    4 publications · 622 citations

    4

    h-index

  2. MF
    Martin F. Fromm

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    4 publications · 836 citations

    4

    h-index

  3. RA
    Robert A. O’Reilly

    Santa Clara Valley Medical Center, United States

    4 publications · 395 citations

    4

    h-index

  4. DA
    Darklis A Goulart

    University of Washington, United States

    3 publications · 338 citations

    3

    h-index

  5. MG
    Milo Gibaldi

    University at Buffalo, State University of New York, United States

    3 publications · 338 citations

    3

    h-index

1–5 of 850

Institutions

275

  1. University of Washington

    Seattle, United States

    10 h-index

    50 publications

    6.6K citations

  2. Karolinska Institutet

    Stockholm, Sweden

    5 h-index

    13 publications

    1K citations

  3. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

    Stuttgart, Germany

    5 h-index

    13 publications

    1.1K citations

  4. Stanford University

    Stanford, United States

    4 h-index

    18 publications

    1.7K citations

  5. Pfizer (United States)

    New York, United States

    4 h-index

    10 publications

    701 citations

  6. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    3 h-index

    10 publications

    253 citations

  7. Cornell University

    Ithaca, United States

    3 h-index

    4 publications

    156 citations

  8. United States Public Health Service

    Washington D.C., United States

    3 h-index

    6 publications

    830 citations

1–8 of 275

Venues

  1. Drug Metabolism and Disposition

    19 publications · 1.6K citations

    18

    h-index

  2. PubMed

    Repository · 20 publications · 596 citations

    16

    h-index

  3. Xenobiotica

    9 publications · 302 citations

    9

    h-index

  4. Clinical Pharmacology & Therapeutics

    CPT · 8 publications · 595 citations

    8

    h-index

  5. British Journal of Clinical Pharmacology

    BJCP · 8 publications · 604 citations

    8

    h-index

1–5