H.K. Crewe

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

H.K. Crewe, MS Lennard, GT Tucker et al. · British Journal of Clinical Pharmacology · 1992 · 468 citations · Full text

Cytochrome P4502d6, Pharmacotherapy, Cyp2d6 Activity +22

Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4′-Hydroxy and N-Desmethyl Metabolites and Isomerization of trans-4-Hydroxytamoxifen

H.K. Crewe, L. Notley, Rebecca M. Wunsch et al. · Drug Metabolism and Disposition · 2002 · 237 citations

Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

H.K. Crewe, S. W. Ellis, M. S. Lennard et al. · Biochemical Pharmacology · 1997 · 223 citations

Molecular Pharmacology, Biochemistry, Medicine +11

Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.

S V Otton, H.K. Crewe, M. S. Lennard et al. · Journal of Pharmacology and Experimental Therapeutics · 1988 · 162 citations

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter‐system extrapolation factors

H.K. Crewe, Zoe Barter, Karen Rowland Yeo et al. · Biopharmaceutics & Drug Disposition · 2011 · 43 citations

Molecular Biology, Inter‐system Extrapolation Factors, Relative Activity +22