Karen Rowland Yeo

Prediction of<i>in vivo</i>drug clearance from<i>in vitro</i>data. I: Impact of inter-individual variability

Eleanor Howgate, Karen Rowland Yeo, N. J. Proctor et al. · Xenobiotica · 2006 · 219 citations

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

Karen Rowland Yeo, Masoud Jamei, Jiansong Yang et al. · European Journal of Pharmaceutical Sciences · 2009 · 185 citations

Systems Pharmacology, Drug Interactions, Molecular Pharmacology +11

Prediction of time-dependent CYP3A4 drug–drug interactions by physiologically based pharmacokinetic modelling: Impact of inactivation parameters and enzyme turnover

Karen Rowland Yeo, Robert L. Walsky, Masoud Jamei et al. · European Journal of Pharmaceutical Sciences · 2011 · 120 citations

Molecular Pharmacology, Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling +9

MECHANISM-BASED INACTIVATION OF CYP2D6 BY METHYLENEDIOXYMETHAMPHETAMINE

Amir Heydari, Karen Rowland Yeo, M. S. Lennard et al. · Drug Metabolism and Disposition · 2004 · 96 citations

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

Jiansong Yang, Masoud Jamei, Amir Heydari et al. · Journal of Psychopharmacology · 2006 · 88 citations

Mechanism-based Inhibition, Pharmacological Study, Biochemistry +13