Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

Karen Rowland Yeo, Masoud Jamei, Jiansong Yang, +2

European Journal of Pharmaceutical Sciences

Systems PharmacologyDrug InteractionsMolecular PharmacologyMechanistic ModellingGut—the Effect +9

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

Jiansong Yang, Masoud Jamei, Amir Heydari, +4

Journal of Psychopharmacology

Mechanism-based InhibitionPharmacological StudyBiochemistryMedicineDrug Discovery +11

Physiologically-based Kinetic Modelling (PBK Modelling): Meeting the 3Rs Agenda

Michel Bouvier d’Yvoire, Pilar Prieto, Bas J. Blaauboer, +18

Alternatives to Laboratory Animals

PhysiologyEcvam Workshop 63Physiologically-based Kinetic ModellingApplied PhysiologyKinetics (Physics) +10

The Consequences of 3,4-Methylenedioxymethamphetamine Induced CYP2D6 Inhibition in Humans

Brian O’Mathúna, Amin Rostami‐Hodjegan, Jiansong Yang, +7

Journal of Clinical Psychopharmacology

Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study

Li Liu, Yunli Yu, Jiansong Yang, +6

Naunyn-Schmiedeberg s Archives of Pharmacology

Beneficial Metabolic EffectsDiabetes ManagementBiochemistryMedicineDiabetic States +8

Kinetic values for mechanism-based enzyme inhibition: Assessing the bias introduced by the conventional experimental protocol

Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, +2

European Journal of Pharmaceutical Sciences

BiochemistryEnzyme CatalysisConventional Experimental ProtocolMechanism-based Enzyme InhibitionEnzyme Specificity +5

Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study

Joanne Ellis, André van Maurik, Léa Fortunato, +20

British Journal of Clinical Pharmacology

Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine‐1‐phosphate receptor modulator, in healthy volunteers

Jianfeng Xu, Frank Gray, Alex Henderson, +4

Clinical Pharmacology in Drug Development

Molecular PharmacologyHypertensionHeart RateBiochemistryG Protein-coupled Receptor +12

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model

Helen Musther, Matthew D. Harwood, Jiansong Yang, +3

Journal of Pharmaceutical Sciences

MechanobiologyStrain-specific PhysiologicallyPharmacokinetic Rat ModelPharmacokinetic ModelingEngineering +8

Increased Oral AUC of Baicalin in Streptozotocin-Induced Diabetic Rats due to the Increased Activity of Intestinal β-Glucuronidase

Li Liu, Yuan‐Xiong Deng, Yan Liang, +6

Planta Medica