Concepedia

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

Karen Rowland Yeo, Masoud Jamei, Jiansong Yang, Geoffrey T. Tucker, Amin Rostami‐Hodjegan

European Journal of Pharmaceutical Sciences · 2009 · 185 citations · 57 references

DOI

Concepts

References

57

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 792 citations

, , +17

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

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Mechanistic Approaches to Volume of Distribution Predictions: Understanding the Processes

Trudy Rodgers, Malcolm Rowland · Pharmaceutical Research · 2007 · 419 citations

, , +11

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

, , +17