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Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

Systems PharmacologyDrug InteractionsMolecular PharmacologyMechanistic ModellingGut—the EffectPharmacokinetic ModelingBiochemistryMedicinePhysiologyComplex Drug–drug InteractionsPharmacologyPhysiologically-based Pharmacokinetic ModelingPharmacokineticsPharmacodynamic Modeling