Concepedia

Time-dependent Inhibition

Time-Dependent Inhibition is a form of enzyme inhibition characterized by a progressive decrease in enzyme activity over time upon incubation of the enzyme with the inhibitor, distinguishing it from rapid-equilibrium inhibition by its dependence on the duration of exposure to the inhibitor.

936

Publications

48.6K

Citations

4.2K

Authors

1K

Institutions

Publications per year

2017–2026

100

Variants

Slow-binding InhibitionSlow-onset Inhibition

Parents

Publications

936

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

, , +16

Enzymes: a practical introduction to structure, mechanism, and data analysis

Choice Reviews Online · 2001 · 1.1K citations

, , +17

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

Valerie B. O’Donnell, David G. Tew, Owen Jones et al. · Biochemical Journal · 1993 · 590 citations · Full text

, , +16

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy

Wilfried Bursch, Adolf Ellinger, Harald Kienzl et al. · Carcinogenesis · 1996 · 511 citations · Full text

, , +13

Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.

Tore Lind, C. Cederberg, Gunnar Ekenved et al. · Gut · 1983 · 503 citations · Full text

, , +13

1–5 of 936

Authors

4.2K

  1. RS
    R. Scott Obach

    Pfizer (United States), United States

    6 publications · 580 citations

    6

    h-index

  2. JT
    Janne T. Backman

    University of Helsinki, Finland

    5 publications · 279 citations

    5

    h-index

  3. AM
    Anne M. Filppula

    University of Helsinki, Finland

    5 publications · 268 citations

    5

    h-index

  4. KE
    Kenneth E. Thummel

    University of Washington, United States

    5 publications · 234 citations

    5

    h-index

  5. RJ
    Russell J. Cox

    University of Bristol, United Kingdom

    4 publications · 92 citations

    4

    h-index

1–5 of 4.2K

Institutions

1K

  1. University of Washington

    Seattle, United States

    14 h-index

    70 publications

    2.5K citations

  2. Pfizer (United States)

    New York, United States

    12 h-index

    76 publications

    3.8K citations

  3. University of Helsinki

    Helsinki, Finland

    9 h-index

    36 publications

    1.6K citations

  4. University of Bristol

    Bristol, United Kingdom

    8 h-index

    20 publications

    1.6K citations

  5. University of Michigan

    Ann Arbor, United States

    8 h-index

    33 publications

    1.3K citations

  6. National Institutes of Health

    Bethesda, United States

    8 h-index

    38 publications

    2.1K citations

  7. Amgen (United States)

    Thousand Oaks, United States

    7 h-index

    26 publications

    663 citations

  8. Washington State University

    Pullman, United States

    7 h-index

    23 publications

    635 citations

1–8 of 1K

Venues

  1. PubMed

    Repository · 72 publications · 2.6K citations

    29

    h-index

  2. Drug Metabolism and Disposition

    45 publications · 2.1K citations

    27

    h-index

  3. Journal of Biological Chemistry

    JBC · 32 publications · 2.4K citations

    25

    h-index

  4. Biochemical Journal

    BJ · 28 publications · 2.4K citations

    22

    h-index

  5. Endocrinology

    26 publications · 1.3K citations

    21

    h-index

1–5