M. S. Lennard

Oxidation Phenotype — A Major Determinant of Metoprolol Metabolism and Response

M. S. Lennard, J H Silas, Stephen Freestone et al. · New England Journal of Medicine · 1982 · 279 citations

Life Sciences, Genetics, Pharmacology +13

Influence of Dose, Cigarette Smoking, Age, Sex, and Metabolic Activity on Plasma Clozapine Concentrations

Amin Rostami‐Hodjegan, Ajmal M. Amin, Edgar P. Spencer et al. · Journal of Clinical Psychopharmacology · 2004 · 275 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4′-Hydroxy and N-Desmethyl Metabolites and Isomerization of trans-4-Hydroxytamoxifen

H.K. Crewe, L. Notley, Rebecca M. Wunsch et al. · Drug Metabolism and Disposition · 2002 · 239 citations

Medicine, Biochemistry, Pharmacology +17

The demethylenation of methylenedioxymethamphetamine (“ecstasy”) by debrisoquine hydroxylase (CYP2D6)

Geoffrey T. Tucker, M. S. Lennard, S. W. Ellis et al. · Biochemical Pharmacology · 1994 · 236 citations

Medicine, Pharmacology, Toxicology +12

Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

H.K. Crewe, S. W. Ellis, M. S. Lennard et al. · Biochemical Pharmacology · 1997 · 223 citations

Medicine, Biochemistry, Pharmacology +11