Concepedia

Metabolic Interaction Modeling

Metabolic Interaction Modeling is a computational or mathematical framework that specifically characterizes the alterations in drug metabolism pathways due to enzyme-mediated interactions, distinguishing it from other drug interaction models by focusing on metabolic clearance mechanisms involving cytochrome P450 and related enzyme systems.

37

Publications

2K

Citations

205

Authors

88

Institutions

Publications per year

2017–2026

14

Parents

Publications

37

Large-scale in silico modeling of metabolic interactions between cell types in the human brain

Nathan E. Lewis, Gunnar Schramm, Aarash Bordbar et al. · Nature Biotechnology · 2010 · 273 citations · Full text

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‘In silico’ simulations to assess the ‘in vivo’ consequences of ‘in vitro’ metabolic drug–drug interactions

Amin Rostami‐Hodjegan, Geoff Tucker · Drug Discovery Today Technologies · 2004 · 239 citations

, , +14

Metabolic interaction models recapitulate leaf microbiota ecology

Martin Schäfer, Alan R. Pacheco, Rahel Künzler et al. · Science · 2023 · 182 citations · Full text

, , +17

Comparison of different approaches to predict metabolic drug-drug interactions

Heidi J. Einolf · Xenobiotica · 2007 · 120 citations

, , +17

A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

Magang Shou, Renke Dai, Dan Cui et al. · Journal of Biological Chemistry · 2001 · 117 citations · Full text

, , +17

1–5 of 37

Authors

205

  1. HJ
    Heidi J. Einolf

    Novartis (United States), United States

    2 publications · 166 citations

    2

    h-index

  2. MD
    Michael D. Pickard

    Massachusetts General Hospital, United States

    1 publications · 17 citations

    1

    h-index

  3. NW
    Ningning Wang

    Central South University, China

    1 publications · 47 citations

    1

    h-index

  4. JA
    Julia A. Vorholt

    ETH Zurich, Switzerland

    1 publications · 182 citations

    1

    h-index

  5. RA
    Randall A. Lewis

    Google (United States), United States

    1 publications · 273 citations

    1

    h-index

1–5 of 205

Institutions

88

  1. United States Military Academy

    West Point, United States

    2 h-index

    7 publications

    603 citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    3 publications

    323 citations

  3. Xiangya Hospital Central South University

    Changsha, China

    1 h-index

    5 publications

    235 citations

  4. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    1 h-index

    2 publications

    364 citations

  5. Indiana University Bloomington

    Bloomington, United States

    1 h-index

    4 publications

    184 citations

  6. The Ohio State University

    Columbus, United States

    1 h-index

    4 publications

    48 citations

  7. Université Claude Bernard Lyon 1

    Villeurbanne, France

    1 h-index

    5 publications

    115 citations

  8. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    8 publications

    400 citations

1–8 of 88

Venues

  1. Xenobiotica

    3 publications · 176 citations

    3

    h-index

  2. CPT Pharmacometrics & Systems Pharmacology

    PSP · 2 publications · 23 citations

    2

    h-index

  3. PLoS Computational Biology

    2 publications · 80 citations

    2

    h-index

  4. Nature Communications

    1 publications · 94 citations

    1

    h-index

  5. European Journal of Pharmaceutical Sciences

    1 publications · 14 citations

    1

    h-index

1–5