Concepedia

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design

Daniel P. Walker, Graciela B. Arhancet, Hwang‐Fun Lu, Steven E. Heasley, Sue Metz, Natasha M. Kablaoui, Francisco M. Franco, Cathleen E. Hanau, Jeffrey A. Scholten, John R. Springer,

Bioorganic & Medicinal Chemistry Letters · 2012 · 27 citations · 10 references

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References

10

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Dale J. Kempf, Kennan C. Marsh, Jon F. Denissen et al. · Proceedings of the National Academy of Sciences · 1995 · 556 citations

, , +16

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Bruce D. Dorsey, Rhonda B. Levin, Joseph P. Vacca et al. · Journal of Medicinal Chemistry · 1994 · 411 citations · Full text

, , +13

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 370 citations

, , +17

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

Natilie Hosea, Wendy T. Collard, Susan Cole et al. · The Journal of Clinical Pharmacology · 2009 · 297 citations

, , +15