Concepedia

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin

Drug Metabolism and Disposition · 2005 · 370 citations · 23 references

DOI

Concepts

References

23

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Kaoxiang Sun · Chinese New Drugs Journal · 2005 · 764 citations

, , +14

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

Harold Boxenbaum · Journal of Pharmacokinetics and Biopharmaceutics · 1982 · 646 citations

, , +11

The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 591 citations

, , +14

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

, , +17