Dermot F. McGinnity

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 364 citations

Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

Alfin D. N. Vaz, Dermot F. McGinnity, Minor J. Coon · Proceedings of the National Academy of Sciences · 1998 · 290 citations · Full text

EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE

Dermot F. McGinnity, Matthew G. Soars, Richard A. Urbanowicz et al. · Drug Metabolism and Disposition · 2004 · 268 citations

From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Brian Springthorpe, A. S. Bailey, Patrick Barton et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 233 citations · Full text

Thrombosis, Platelet Aggregation Inhibitors, Biochemistry +8

Automated Definition of the Enzymology of Drug Oxidation by the Major Human Drug Metabolizing Cytochrome P450s

Dermot F. McGinnity, Alison J. Parker, Matthew G. Soars et al. · Drug Metabolism and Disposition · 2000 · 122 citations