Dermot F. McGinnity

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 370 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

Alfin D. N. Vaz, Dermot F. McGinnity, Minor J. Coon · Proceedings of the National Academy of Sciences · 1998 · 292 citations

Medicine, Biochemistry, Toxicology +17

EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE

Dermot F. McGinnity, Matthew G. Soars, Richard A. Urbanowicz et al. · Drug Metabolism and Disposition · 2004 · 268 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Brian Springthorpe, A. S. Bailey, Patrick Barton et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 235 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Evaluation of Human Pharmacokinetics, Therapeutic Dose and Exposure Predictions Using Marketed Oral Drugs

Dermot F. McGinnity, John Collington, Rupert P. Austin et al. · Current Drug Metabolism · 2007 · 125 citations

Pharmacy, Pharmacokinetics, Pharmacology +14