Brian Springthorpe

From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Brian Springthorpe, A. S. Bailey, Patrick Barton et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 233 citations · Full text

Thrombosis, Platelet Aggregation Inhibitors, Biochemistry +8

Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships

Igor L. Shamovsky, Stephen Connolly, Laurent David et al. · Journal of Medicinal Chemistry · 2008 · 49 citations · Full text

Inflammation, Selectivity Issues, Medicinal Chemistry +15

Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo

Iain Martin, Richard J. Lewis, Michael A. Bernstein et al. · Drug Metabolism and Disposition · 2006 · 39 citations

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Ash Bahl, Patrick Barton, Keith Bowers et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 20 citations · Full text

Medicinal Chemistry, Medicine, Natural Sciences +9

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

Ash Bahl, Patrick Barton, Keith Bowers et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 17 citations · Full text

Signal Transduction, Functional Selectivity, Medicine +10