Laurent David

Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships

Igor L. Shamovsky, Stephen Connolly, Laurent David et al. · Journal of Medicinal Chemistry · 2008 · 49 citations · Full text

Inflammation, Selectivity Issues, Medicinal Chemistry +15

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

D.S. Williamson, Garrick P. Smith, P. Acheson-Dossang et al. · Journal of Medicinal Chemistry · 2017 · 47 citations · Full text

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

Tenna Juul Schrøder, Søren Christensen, Samsa Lindberg et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 44 citations · Full text

Medicine, Vps10p Family, Receptor Sortilin +8

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex

Jacob Lauwring Andersen, Tenna Juul Schrøder, Søren Christensen et al. · Acta Crystallographica Section D Biological Crystallography · 2014 · 34 citations · Full text

Molecular Biology, Peptide Science, Synaptic Signaling +21

The identification of GPR3 inverse agonist AF64394; The first small molecule inhibitor of GPR3 receptor function

Thomas Jensen, Lisbeth Elster, Søren Nielsen et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 32 citations

Molecular Pharmacology, Signal Transduction, G Protein-coupled Receptor +10