Iain Martin

Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization

Randy R. Miller, Maria Madeira, Harold B. Wood et al. · Journal of Medicinal Chemistry · 2020 · 134 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

(<i>S</i>)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D₄ Antagonist

Ruth E. TenBrink, Carol L. Bergh, J. Neil Duncan et al. · Journal of Medicinal Chemistry · 1996 · 98 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia

Andreas Varkaris, Ermira Pazolli, Hakan Günaydin et al. · Cancer Discovery · 2023 · 90 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +17

Synthesis and Biological Activities of (<i>R</i>)-5,6-Dihydro-<i>N</i>,<i>N</i>-dimethyl-4<i>H</i>-imidazo[4,5,1-<i>ij</i>]quinolin-5-amine and Its Metabolites

Richard F. Heier, Lester A. Dolak, J. Neil Duncan et al. · Journal of Medicinal Chemistry · 1997 · 73 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Evaluation of a series of bicyclic CXCR2 antagonists

Iain A. S. Walters, Caroline A. Austin, Rupert P. Austin et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 62 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12