Maria Madeira

Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization

Randy R. Miller, Maria Madeira, Harold B. Wood et al. · Journal of Medicinal Chemistry · 2020 · 134 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Blockade of microglial adenosine A_2A receptor suppresses elevated pressure‐induced inflammation, oxidative stress, and cell death in retinal cells

Inês Aires, Raquel Boia, Ana Catarina Rodrigues‐Neves et al. · Glia · 2019 · 92 citations · Full text

Medicine, Ophthalmology, Pharmacology +17

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

Maria Madeira, Filipe Elvas, Raquel Boia et al. · Journal of Neuroinflammation · 2015 · 84 citations · Full text

Medicine, Neurobiology, Pharmacology +17

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

Maria Madeira, Raquel Boia, Filipe Elvas et al. · Translational research · 2015 · 84 citations

Medicine, Neuroscience, Ophthalmology +16

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1 <i>H</i> -benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Tim Cernak, Nathan J. Gesmundo, Kevin D. Dykstra et al. · Journal of Medicinal Chemistry · 2017 · 84 citations · Full text

Pharmacy, Chemistry, Pharmacology +11