Concepedia

From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Brian Springthorpe, A. S. Bailey, Patrick Barton, Timothy N. Birkinshaw, Roger V. Bonnert, Roger C. Brown, David A. Chapman, John Dixon, Simon D. Guile, Robert G. Humphries,

Bioorganic & Medicinal Chemistry Letters · 2007 · 235 citations · 13 references

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References

13

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)

The Lancet · 1996 · 6.5K citations

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Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation

New England Journal of Medicine · 2001 · 6.5K citations · Full text

, , +13

Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin

Steen Husted, Håkan Emanuelsson, Stan Heptinstall et al. · European Heart Journal · 2006 · 740 citations · Full text

, , +15

Antagonists of the Platelet P<i><sub>2T</sub></i> Receptor:  A Novel Approach to Antithrombotic Therapy

Anthony H. Ingall, John Dixon, Andrew Bailey et al. · Journal of Medicinal Chemistry · 1999 · 285 citations

, , +17

Purinergic approaches in experimental therapeutics

European Journal of Medicinal Chemistry · 1997 · 256 citations

, , +9