Simon D. Guile

From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Brian Springthorpe, A. S. Bailey, Patrick Barton et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 233 citations · Full text

Thrombosis, Platelet Aggregation Inhibitors, Biochemistry +8

A novel palladium-catalyzed cycloalkylation to isoxazoline 2-oxides. Application for the asymmetric synthesis of carbanucleosides.

Barry M. Trost, Leping Li, Simon D. Guile · Journal of the American Chemical Society · 1992 · 154 citations

Engineering, Asymmetric Synthesis, Altmetric Attention Score +11

Palladium-Catalyzed Enantioselective Synthesis of Carbanucleosides

Barry M. Trost, Robert Madsen, Simon D. Guile et al. · Journal of the American Chemical Society · 2000 · 92 citations

Optimization of Monocarboxylate Transporter 1 Blockers through Analysis and Modulation of Atropisomer Interconversion Properties

Simon D. Guile, John R. Bantick, Martin Cooper et al. · Journal of Medicinal Chemistry · 2006 · 67 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +15

Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules

Tim Luker, Lilian Alcaraz, Kamaldeep K. Chohan et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 57 citations

Vivo Toxicology Outcomes, Preclinical Drug Evaluation, Pharmacological Study +6